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By Andrej Čretnik

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2010). Relationship between muscle strength, power and stiffness and running economy in trained male runners. International journal of sports physiology and performance, 5(2), 249– 261. Egli RJ, Southam L, Wilkins JM, Lorenzen I, Pombo-Suarez M, Gonzalez A, Carr A, Chapman K, and Loughlin J. (2009). Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. Arthritis & Rheumatism 60: 2055-2064. , & Birk, D. E. (2000). Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons.

In addition variant rs12722 within the COL5A1 3’UTR is in close proximity with two polymorphic putative miRNA binding sites within the COL5A1 3’-UTR (September et al, 2009). Due to the structural similarities of tendon and ligaments at the molecular level, the association of the COL5A1 rs12722 variant with another musculoskeletal soft tissue injury, namely anterior cruciate ligament (ACL) rupture, was investigated. Within females the, CC genotype of SNP rs12722 was significantly underrepresented among the cases (Posthumus et al, 2009).

The abundance of group O was even higher (69%) in individuals who had sustained a re-rupture (Jozsa et al, 1989). Subsequent studies by Kujala and colleagues 28 Achilles Tendon (Kujala et al, 1992) and Kannus and Natri (Kannus & Natri, 1997 as cited by September, 2007) have documented associations between Achilles tendon rupture and blood group distribution. Interestingly, the relationship between blood group distribution and risk of Achilles tendon rupture was not observed in subsequent work involving 215 Achilles patients recruited in a Finnish cohort (Leppilahti et al, 1996), 78 patients in a Scottish based cohort (Maffulli et al, 2000) and in a small South African based study involving 75 rupture cases and 131 controls (Mokone, 2006 as cited by September 2007).

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